Oftentimes on this channel we discuss the issue of taking edibles, not feeling an effect and taking more only to be floored hours later and put out of commission for a day. We know that this happens because of the route of administration of the edible but why does it really take so long for absorption and eventual relief many are seeking? I have a very intriguing conversation with Dr. Peshkovsky!
Last year I discussed 6 ways to ensure nanoemulsion stability (https://www.youtube.com/watch?v=UMh_A45euwc) and quite a few folks were interested in that topic and so when the opportunity arose to have a discussion with Dr. Alexey Peshkovsky – President @IndustrialSonomechanics I figured my subscribers could get a lot of out this.
So here it is, we’re discussing their groundbreaking paper Pharmacokinetics of Two Nanoemulsion formulations of d8-tetrahydrocannabinol in Rats published at AAPS PharmSciTech, an official journal of The American Association of Pharmaceutical Scientists.
The manuscript is a preclinical pharmacokinetic study comparing two orally administered Δ8-THC nanoemulsions (liquid and powdered) with a Δ8-THC solution in MCT oil.
CHAPTERS:
2:38 – Dr. Peshkovsky’s Background
13:00 – Manuscript overview
20:25 – Would delivery of product differ if this were THC?
23:00 – How did they make the powder nanoemulsion?
27:27 – Nanoemulsions outperform MCT oil by 19X in 1st hour
31:24 – Empty stomach vs full stomach bioavailability. Nanoemulsions don’t need food.
38:20 – Why was the droplet size irrelevant between the liquid and powder?
42:20 – When manufacturers claim greater bioavailability, is this true or is it false advertising?
46:00 – Viewer question: what’s the best way to break a stable nanoemulsion and measure it?
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