This was my most recent Cleveland Clinic Neurology Grand Rounds lecture on 9/3/19, titled “Cannabis and Cannabinoids in Migraine and Chronic Pain: Benefits, Harms, and Legal Implications”. This provides a brief historical perspective, reviews the major cannabinoids CBD and THC including a discussion on CBD products, describes the terpenes, reviews the more scientific and current chemovar (Types I, II, III) classification and contrasts it with the older cultivar classification (Sativa, Indica, Hemp/Ruderalis), summarizes the scientific literature for cannabis/cannabinoid use in chronic pain and migraine/headache, provides clinical use highlights and guidelines, reviews potential harms and adverse effects of cannabis (including cannabis…
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